The high-risk populations to get syphilis is women of childbearing age, sexually active teens, drug users, inmates of penal institutions, and a persons with multiple sexual partners or those who have sex with prostitutes.

A syphilis symptoms  in women we can divide in two, there is :

1. Primary syphilis

Genital ulcer: painless ulcer with clean base and firm indurated border, Regional lymphadenopathy

2.  Secondary syphilis
Skin and mucous membranes
Rash: diffuse (including palms and soles), macular, papular, pustular, and combinations
Condylomata lata
Mucous patches: painless, silvery ulcerations of mucous membrane with surrounding erythema
Generalized lymphadenopathy
Constitutional symptoms
Fever, usually low-grade
Malaise
Anorexia
Arthralgias and myalgias
Central nervous system
Asymptomatic
Symptomatic
Headache
Meningitis
Cranial neuropathies (II–VIII)
Ocular
Iritis
Iridocyclitis

Patients with infectous syphilis must abstain from sexual activity until rendered noninfectious by antibiotic therapy. All cases of syphilis must be reported to the appropriate public health agency for assistance in identifying and treating contacts. In addition, all patients with syphilis should have an HIV test at the time of diagnosis. In areas of high HIV prevalence, a repeat HIV test should be performed in 3 months if the initial test was negative.